Guterres Calls to End AIDS Epidemic Once and For All on World AIDS Day 2025

On December 1, 2025, António Manuel de Oliveira Guterres, the ninth United Nations Secretary-General, delivered a powerful appeal to the world: "We have the power to transform lives and futures, and end the AIDS epidemic once and for all." The message, broadcast globally through UN channels from Vienna to Bangkok and Kyiv, wasn’t just ceremonial—it was a direct challenge to governments, donors, and communities still falling short in the fight against HIV. The timing mattered. This was World AIDS Day 2025, the 37th annual observance, and for the first time in over a decade, the world stands at a crossroads: we have the tools to end AIDS, but not the will to distribute them equally.

Global Coordination, Uneven Progress

The United Nations didn’t just release one statement. It orchestrated a symphony of voices. Alongside Guterres, the UNAIDS, the World Health Organization, the United Nations Development Programme, the United Nations Population Fund, and the Government of South Africa all issued statements. This wasn’t coincidence. It was strategy. The message was clear: ending AIDS isn’t a health issue alone—it’s a development, human rights, and economic imperative. And yet, behind the unified front, the data tells a more complicated story.

According to the Citizen Portal AI report from the same day, the UN acknowledged "long-term progress on HIV alongside persistent gaps in prevention and treatment access." That truncated phrase is the heart of the crisis. We’ve reduced new infections by 52% since 2010 and AIDS-related deaths by 69% since their 2004 peak. But those numbers hide the fractures. In Eastern Europe and Central Asia, new infections rose 60% between 2010 and 2023. In sub-Saharan Africa, where 67% of all people living with HIV reside, nearly 1 in 4 still don’t know their status. And in the U.S., Black and Latino communities account for more than 70% of new diagnoses despite making up just 30% of the population.

Why This Year Feels Different

This isn’t the first time Guterres has called for an end to AIDS. But something shifted in 2025. For the first time since 2016, global funding for HIV programs plateaued—$20.7 billion in 2024, down from $22.4 billion in 2022. Meanwhile, inflation, donor fatigue, and competing crises have pushed HIV to the back of policy agendas. The United Nations knew this. That’s why the 2025 message avoided numbers and instead leaned on moral urgency. It didn’t say "we must reach 95-95-95 targets by 2030." It said: "We have the power." That’s intentional. It’s a reminder that the tools—antiretroviral therapy, PrEP, needle exchanges, community-led outreach—already exist. What’s missing is equity.

"The people being left behind aren’t faceless statistics," said Dr. Naledi Pandor, former South African Minister of Health, in a separate interview with The Lancet on December 2. "They’re young women in rural Mozambique who can’t get PrEP because the clinic is 40 kilometers away. They’re gay men in Russia who fear arrest if they seek testing. They’re transgender youth in Brazil whose insurance won’t cover their medication. This isn’t about science anymore. It’s about justice."

The Political Silence

What’s striking about the 2025 campaign is what it didn’t include. No new funding pledges. No deadlines. No country-specific commitments. Even the Government of South Africa, which has the world’s largest antiretroviral program, didn’t announce a budget increase. The United Nations has learned the hard way: when you ask for money in a time of war, climate disasters, and inflation, you get silence. So they changed tactics. Instead of asking for cash, they asked for conscience.

The UNAIDS website lists over 40 statements from member states and agencies, yet only Guterres’s was distributed universally. Why? Because his voice carries weight. He’s not just a diplomat—he’s the last global figure with the platform to shame nations into action. And he did. In Vienna, the United Nations Information Service released the message under document reference UNISSGSM1538. In Thailand, the United Nations office published it under the exact same wording. No edits. No dilution. The message was sacred.

What Comes Next?

What Comes Next?

The United Nations won’t issue another major statement until the High-Level Meeting on HIV in September 2026. But behind the scenes, teams are already mapping where the gaps are deepest. The UNFPA is pushing to integrate HIV services into maternal care in 12 high-burden countries. The WHO is finalizing new guidelines on long-acting injectables for PrEP, which could revolutionize adherence in rural areas. And in South Africa, community health workers are now being trained to deliver HIV self-tests via mobile vans—a model that cut diagnosis delays by 58% in a pilot in KwaZulu-Natal.

But none of this will matter unless political leaders stop treating AIDS as a past crisis. The last time the world came close to ending AIDS was in 2016, when UN member states pledged to end it by 2030. We’re 5 years in, and progress is stalling. Guterres’s message wasn’t a report card. It was a wake-up call. And this time, the world better listen.

Background: The Long Road to 2025

The United Nations began formally recognizing World AIDS Day in 1988, making it the first global health day ever established by the UN. In 2001, the Global Fund to Fight AIDS, Tuberculosis and Malaria was created with $1.2 billion in pledges. By 2010, antiretroviral therapy was available to 6.6 million people—up from just 400,000 in 2005. In 2015, the United Nations set the 95-95-95 targets: 95% of people with HIV knowing their status, 95% on treatment, and 95% virally suppressed. In 2023, global figures stood at 86-91-93. Close, but not enough.

What’s often forgotten is that AIDS was once a death sentence. In the 1980s, it killed more than 1.5 million people a year. Today, it kills about 630,000—still too many, but a fraction of what it was. The difference? Science, activism, and relentless pressure from people who refused to be silenced. Now, the challenge isn’t curing HIV—it’s ensuring no one is left behind because of where they live, who they love, or how much money they have.

Frequently Asked Questions

How does this affect people living with HIV today?

Despite medical advances, over 1.3 million new HIV infections occurred in 2023, and 630,000 people died from AIDS-related causes. The biggest barrier isn’t medicine—it’s access. In 30 countries, less than half of people with HIV are on treatment. Marginalized groups—sex workers, transgender people, LGBTQ+ youth, and incarcerated populations—are disproportionately affected and often denied services due to stigma or laws.

Why didn’t Guterres announce new funding or targets?

With global donor funding flatlining since 2022 and competing crises like Ukraine and Gaza dominating headlines, the United Nations shifted strategy. Instead of asking for money it might not get, it focused on moral leadership. The goal was to reignite political will, not make promises that might go unfulfilled. The real funding push comes at the September 2026 UN High-Level Meeting.

What’s the biggest obstacle to ending AIDS now?

It’s not science—it’s inequality. In places like Eastern Europe, punitive laws against drug use and homosexuality block prevention programs. In the U.S., Medicaid gaps leave thousands without coverage. In sub-Saharan Africa, health systems are underfunded and understaffed. Ending AIDS requires fixing not just clinics, but justice systems, gender norms, and economic structures that keep people vulnerable.

Is the 2030 goal still achievable?

Technically, yes—but only if current trends reverse. At the 2023 pace, the world won’t reach the 95-95-95 targets until 2035. To hit 2030, new infections must drop by 75% and treatment access must expand to 12 million more people. That requires $29 billion annually by 2027, up from $20.7 billion in 2024. Without a major funding surge and policy reform, the goal will slip further out of reach.

How can individuals help end the AIDS epidemic?

Support community-led organizations that provide testing and care to marginalized groups. Advocate for policies that decriminalize HIV transmission and protect LGBTQ+ rights. Donate to groups like the Global Fund or local AIDS foundations. And challenge stigma—every time someone says "AIDS is over," they’re erasing the reality of millions still fighting for care.

What role does South Africa play in the global response?

South Africa has the world’s largest HIV treatment program, with over 5.7 million people on antiretrovirals. It pioneered community health worker models and was the first country to provide free PrEP nationwide. But it still faces challenges: high infection rates among young women, drug resistance, and clinic overcrowding. Its leadership is critical—not just for Africa, but as a model for how large-scale HIV response can work when political will exists.